Purine nucleoside phosphorylase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P85973. Use UniProt P85973 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P85973 as the stable identity anchor, then attach disease evidence before program review.
Purine nucleoside phosphorylase
Review this target as Purine nucleoside phosphorylase, mapped to UniProt P85973. Sequence length is 289 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Purine nucleoside phosphorylase as ChEMBL target CHEMBL2395, mapped to UniProt P85973. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Purine nucleoside phosphorylase is the right protein anchor across sources, using UniProt P85973 as the stable mapping.
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| Preferred Name | Purine nucleoside phosphorylase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P85973 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Purine nucleoside phosphorylase |
| UniProt Accession | P85973 |
| Component Type | Protein |
| Sequence Length | 289 aa |
Purine nucleoside phosphorylase
Review this target as Purine nucleoside phosphorylase, mapped to UniProt P85973. Sequence length is 289 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL315570 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL81839 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL311300 | 7.6 | IC50 | 25.0 | Clinical |
| CHEMBL79784 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL81348 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL310458 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL56593 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL81055 | 7.46 | IC50 | 35.0 | Preclinical |
| CHEMBL83053 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL13448 | 7.36 | IC50 | 44.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 4 | 29 | 6.4 |
| single protein format | 3 | 0 | — |