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Target Snapshot

CHEMBL2396505 Target Snapshot

Genome polyprotein · SINGLE PROTEIN · Coxsackievirus B3 (strain Nancy)

140Compounds
25Assays
0Approved Drugs
118.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P03313. Use UniProt P03313 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P03313 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Genome polyprotein as ChEMBL target CHEMBL2396505, mapped to UniProt P03313. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Genome polyprotein
SINGLE PROTEIN · Coxsackievirus B3 (strain Nancy)
As of 2026-09-14
ChEMBL target ID
CHEMBL2396505
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P03313
Genome polyprotein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Genome polyprotein is the right protein anchor across sources, using UniProt P03313 as the stable mapping.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGenome polyprotein
UniProt AccessionP03313
Component TypeProtein
Sequence Length2185 aa

Genome polyprotein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Genome polyprotein, mapped to UniProt P03313. Sequence length is 2185 aa.

Mapped IDP03313
Review nameGenome polyprotein
OrganismCoxsackievirus B3 (strain Nancy)
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC50113.0
KI5.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3968123 7.16 IC50 70.0 Preclinical
CHEMBL3968504 7.1 IC50 80.0 Preclinical
CHEMBL3896963 7.0 IC50 100.0 Preclinical
CHEMBL3924623 6.96 IC50 110.0 Preclinical
CHEMBL3938952 6.96 IC50 110.0 Preclinical
CHEMBL3984899 6.92 IC50 120.0 Preclinical
CHEMBL2164935 6.89 IC50 130.0 Preclinical
CHEMBL2164929 6.8 IC50 160.0 Preclinical
CHEMBL3955342 6.8 IC50 160.0 Preclinical
CHEMBL2164928 6.77 IC50 170.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
13
5.5
43
6.0
23
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

25
Total Assays
98
Tested Compounds
1
Assay Types
Binding — 25 assays, 98 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 24 97 6.0
single protein format 1 1 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine