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Target Snapshot

CHEMBL2396508 Target Snapshot

Receptor-type tyrosine-protein phosphatase S · SINGLE PROTEIN · Homo sapiens

64Compounds
17Assays
0Approved Drugs
62.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q13332. Use UniProt Q13332 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q13332 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Receptor-type tyrosine-protein phosphatase S as ChEMBL target CHEMBL2396508, mapped to UniProt Q13332. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Receptor-type tyrosine-protein phosphatase S
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2396508
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q13332
Receptor-type tyrosine-protein phosphatase S
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Receptor-type tyrosine-protein phosphatase S is the right protein anchor across sources, using UniProt Q13332 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelReceptor-type tyrosine-protein phosphatase S
UniProt AccessionQ13332
Component TypeProtein
Sequence Length1948 aa

Receptor-type tyrosine-protein phosphatase S

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Receptor-type tyrosine-protein phosphatase S, mapped to UniProt Q13332. Sequence length is 1948 aa.

Mapped IDQ13332
Review nameReceptor-type tyrosine-protein phosphatase S
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5062.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1438439 6.3 IC50 500.0 Preclinical
CHEMBL3633138 6.22 IC50 600.0 Preclinical
CHEMBL55415 6.22 IC50 600.0 Preclinical
CHEMBL3739950 6.1 IC50 800.0 Preclinical
CHEMBL3633139 6.05 IC50 900.0 Preclinical
CHEMBL3740878 6.05 IC50 900.0 Preclinical
CHEMBL398328 5.52 IC50 3000.0 Preclinical
CHEMBL1829872 5.44 IC50 3600.0 Preclinical
CHEMBL1829864 5.37 IC50 4300.0 Preclinical
CHEMBL28626 5.37 IC50 4300.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
1
5.5
6
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

17
Total Assays
29
Tested Compounds
1
Assay Types
Binding — 17 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 15 28 5.3
assay format 1 1 4.4
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine