Use UniProt Q9HX69 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2396510 Target Snapshot
Cyclic di-GMP phosphodiesterase RocR · SINGLE PROTEIN · Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)
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As of 2026-09-14Protein identity stays anchored to UniProt Q9HX69. Use UniProt Q9HX69 as the stable identity anchor, then attach disease evidence before program review.
Cyclic di-GMP phosphodiesterase RocR
Review this target as Cyclic di-GMP phosphodiesterase RocR, mapped to UniProt Q9HX69. Sequence length is 392 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Cyclic di-GMP phosphodiesterase RocR as ChEMBL target CHEMBL2396510, mapped to UniProt Q9HX69. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclic di-GMP phosphodiesterase RocR |
| Target Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
| UniProt | Q9HX69 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclic di-GMP phosphodiesterase RocR |
| UniProt Accession | Q9HX69 |
| Component Type | Protein |
| Sequence Length | 392 aa |
Cyclic di-GMP phosphodiesterase RocR
How to read this target
Review this target as Cyclic di-GMP phosphodiesterase RocR, mapped to UniProt Q9HX69. Sequence length is 392 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1231573 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL2398348 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL2398349 | 6.14 | IC50 | 720.0 | Preclinical |
| CHEMBL2398347 | 5.19 | IC50 | 6410.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 2 assays, 4 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 4 | 6.7 |