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Target Snapshot

CHEMBL2396510 Target Snapshot

Cyclic di-GMP phosphodiesterase RocR · SINGLE PROTEIN · Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)

4Compounds
2Assays
0Approved Drugs
4.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9HX69. Use UniProt Q9HX69 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9HX69 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cyclic di-GMP phosphodiesterase RocR as ChEMBL target CHEMBL2396510, mapped to UniProt Q9HX69. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cyclic di-GMP phosphodiesterase RocR
SINGLE PROTEIN · Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)
As of 2026-09-14
ChEMBL target ID
CHEMBL2396510
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9HX69
Cyclic di-GMP phosphodiesterase RocR
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cyclic di-GMP phosphodiesterase RocR is the right protein anchor across sources, using UniProt Q9HX69 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCyclic di-GMP phosphodiesterase RocR
UniProt AccessionQ9HX69
Component TypeProtein
Sequence Length392 aa

Cyclic di-GMP phosphodiesterase RocR

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cyclic di-GMP phosphodiesterase RocR, mapped to UniProt Q9HX69. Sequence length is 392 aa.

Mapped IDQ9HX69
Review nameCyclic di-GMP phosphodiesterase RocR
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)
Assay Mix

Activity Type Distribution

IC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1231573 7.7 IC50 20.0 Preclinical
CHEMBL2398348 7.7 IC50 20.0 Preclinical
CHEMBL2398349 6.14 IC50 720.0 Preclinical
CHEMBL2398347 5.19 IC50 6410.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
1
6.0
0
6.5
0
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
4
Tested Compounds
1
Assay Types
Binding — 2 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 4 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine