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Target Snapshot

CHEMBL2406894 Target Snapshot

Alkaline phosphatase, tissue-nonspecific isozyme · SINGLE PROTEIN · Bos taurus

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102Compounds
13Assays
2Approved Drugs
126.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P09487. Use UniProt P09487 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P09487 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alkaline phosphatase, tissue-nonspecific isozyme as ChEMBL target CHEMBL2406894, mapped to UniProt P09487. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alkaline phosphatase, tissue-nonspecific isozyme
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL2406894
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P09487
Alkaline phosphatase, tissue-nonspecific isozyme
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alkaline phosphatase, tissue-nonspecific isozyme is the right protein anchor across sources, using UniProt P09487 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameAlkaline phosphatase, tissue-nonspecific isozyme
Target TypeSINGLE PROTEIN
OrganismBos taurus
UniProtP09487
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlkaline phosphatase, tissue-nonspecific isozyme
UniProt AccessionP09487
Component TypeProtein
Sequence Length524 aa

Alkaline phosphatase, tissue-nonspecific isozyme

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alkaline phosphatase, tissue-nonspecific isozyme, mapped to UniProt P09487. Sequence length is 524 aa.

Mapped IDP09487
Review nameAlkaline phosphatase, tissue-nonspecific isozyme
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5071.0
KI55.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3403324 7.3 Ki 50.0 Preclinical
CHEMBL3403327 7.22 Ki 60.0 Preclinical
CHEMBL182659 7.16 Ki 70.0 Preclinical
CHEMBL3797297 7.11 Ki 78.0 Preclinical
CHEMBL5595268 6.96 IC50 110.0 Preclinical
CHEMBL3403324 6.94 IC50 115.0 Preclinical
CHEMBL2408701 6.89 Ki 130.0 Preclinical
CHEMBL3403329 6.89 Ki 128.0 Preclinical
CHEMBL3403327 6.82 IC50 150.0 Preclinical
CHEMBL182659 6.75 IC50 180.0 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
18
5.5
8
6.0
16
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

13
Total Assays
88
Tested Compounds
2
Assay Types
Binding — 10 assays, 88 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 88 5.4
assay format 1 0 —
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine