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Target Snapshot

CHEMBL2414 Target Snapshot

C-C chemokine receptor type 4 · SINGLE PROTEIN · Homo sapiens

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1,592Compounds
152Assays
6Approved Drugs
2,585.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

C-C chemokine receptor type 4 shows approved-linked disease relevance led by mycosis fungoides. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P51679. Start with mycosis fungoides, then reuse UniProt P51679 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with mycosis fungoides, then reuse UniProt P51679 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
mycosis fungoides

C-C chemokine receptor type 4 shows approved-linked disease relevance led by mycosis fungoides. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with mycosis fungoides because it currently carries approved-linked support. Linked drugs include MOGAMULIZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-C chemokine receptor type 4 as ChEMBL target CHEMBL2414, mapped to UniProt P51679. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-C chemokine receptor type 4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2414
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P51679
C-C chemokine receptor type 4
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-C chemokine receptor type 4 is the right protein anchor across sources, using UniProt P51679 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why mycosis fungoides is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameC-C chemokine receptor type 4
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP51679
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-C chemokine receptor type 4
UniProt AccessionP51679
Component TypeProtein
Sequence Length360 aa

C-C chemokine receptor type 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C-C chemokine receptor type 4, mapped to UniProt P51679. Sequence length is 360 aa.

Mapped IDP51679
Review nameC-C chemokine receptor type 4
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

C-C chemokine receptor type 4 shows approved-linked disease relevance led by mycosis fungoides. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
mycosis fungoides
1 linked drug · 1 direct · 1 efficacy
Linked drugMOGAMULIZUMAB
Approved-linked Approved
neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugMOGAMULIZUMAB
Approved-linked Approved
Sezary's disease
1 linked drug · 1 direct · 1 efficacy
Linked drugMOGAMULIZUMAB
Late clinical Phase III
Cutaneous T-cell lymphoma
1 linked drug · 1 direct · 1 efficacy
Linked drugMOGAMULIZUMAB
Late clinical Phase III
tropical spastic paraparesis
1 linked drug · 1 direct · 1 efficacy
Linked drugMOGAMULIZUMAB
Clinical signal Phase II
adult T-cell leukemia/lymphoma
1 linked drug · 1 direct · 1 efficacy
Linked drugMOGAMULIZUMAB
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with mycosis fungoides because it currently carries approved-linked support. Linked drugs include MOGAMULIZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasemycosis fungoides
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

6
Approved
1
Phase III
2
Phase I
Assay Mix

Activity Type Distribution

IC501,585.0
KI937.0
EC509.0
KD54.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4172769 9.5 IC50 0.3162 Preclinical
CHEMBL4167445 9.2 IC50 0.631 Preclinical
CHEMBL2018953 9.1 Ki 0.7943 Preclinical
CHEMBL3797662 9.0 Ki 1.0 Preclinical
CHEMBL4162364 9.0 IC50 1.0 Preclinical
CHEMBL3799266 8.8 Ki 1.585 Preclinical
CHEMBL372399 8.6 Ki 2.512 Preclinical
CHEMBL3797537 8.6 Ki 2.512 Preclinical
CHEMBL4172635 8.6 IC50 2.512 Preclinical
CHEMBL4160218 8.6 IC50 2.512 Preclinical
Distribution

pChEMBL Value Distribution

74
5.0
81
5.5
147
6.0
166
6.5
101
7.0
78
7.5
37
8.0
9
8.5
4
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

ITRACONAZOLE
CHEMBL64391
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

152
Total Assays
404
Tested Compounds
2
Assay Types
Binding — 98 assays, 404 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 61 51 6.0
cell-based format 33 265 6.1
assay format 2 67 6.4
cell membrane format 2 21 6.9
Functional — 54 assays, 276 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 39 230 7.0
assay format 11 18 6.8
single protein format 2 0 —
cell membrane format 1 17 7.3
tissue-based format 1 11 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine