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Target Snapshot

CHEMBL2417346 Target Snapshot

Oxysterols receptor LXR-beta · SINGLE PROTEIN · Mus musculus

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62Compounds
18Assays
0Approved Drugs
17.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q60644. Use UniProt Q60644 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q60644 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Oxysterols receptor LXR-beta as ChEMBL target CHEMBL2417346, mapped to UniProt Q60644. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Oxysterols receptor LXR-beta
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2417346
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q60644
Oxysterols receptor LXR-beta
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Oxysterols receptor LXR-beta is the right protein anchor across sources, using UniProt Q60644 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameOxysterols receptor LXR-beta
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtQ60644
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOxysterols receptor LXR-beta
UniProt AccessionQ60644
Component TypeProtein
Sequence Length446 aa

Oxysterols receptor LXR-beta

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Oxysterols receptor LXR-beta, mapped to UniProt Q60644. Sequence length is 446 aa.

Mapped IDQ60644
Review nameOxysterols receptor LXR-beta
OrganismMus musculus
Assay Mix

Activity Type Distribution

EC5017.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL595124 7.92 EC50 12.0 Preclinical
CHEMBL62136 7.57 EC50 27.0 Preclinical
CHEMBL606157 7.43 EC50 37.0 Preclinical
CHEMBL214719 7.39 EC50 41.0 Preclinical
CHEMBL604479 6.96 EC50 111.0 Preclinical
CHEMBL593960 6.85 EC50 141.0 Preclinical
CHEMBL596262 6.78 EC50 168.0 Preclinical
CHEMBL4208321 6.52 EC50 300.0 Preclinical
CHEMBL4215604 6.52 EC50 300.0 Preclinical
CHEMBL595118 6.26 EC50 555.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
4
6.0
5
6.5
2
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

18
Total Assays
8
Tested Compounds
2
Assay Types
Binding — 16 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 4 6.1
single protein format 1 2 6.3
Functional — 2 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 8 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine