Estrogen receptor beta · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Estrogen receptor beta shows approved-linked disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q92731. Start with breast cancer, then reuse UniProt Q92731 as the stable protein anchor across project notes and exports.
Start with breast cancer, then reuse UniProt Q92731 as the stable protein anchor across project notes and exports.
Estrogen receptor beta shows approved-linked disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with breast cancer because it currently carries approved-linked support. Linked drugs include AUS-131, ESTRAMUSTINE PHOSPHATE SODIUM, RALOXIFENE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEstrogen receptor beta
Review this target as Estrogen receptor beta, mapped to UniProt Q92731. Sequence length is 530 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Estrogen receptor beta as ChEMBL target CHEMBL242, mapped to UniProt Q92731. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Estrogen receptor beta is the right protein anchor across sources, using UniProt Q92731 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why breast cancer is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Estrogen receptor beta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q92731 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Estrogen receptor beta |
| UniProt Accession | Q92731 |
| Component Type | Protein |
| Sequence Length | 530 aa |
Estrogen receptor beta
Review this target as Estrogen receptor beta, mapped to UniProt Q92731. Sequence length is 530 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Estrogen receptor beta shows approved-linked disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block.
Start review with breast cancer because it currently carries approved-linked support. Linked drugs include AUS-131, ESTRAMUSTINE PHOSPHATE SODIUM, RALOXIFENE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL135 | 11.0 | EC50 | 0.01 | Approved |
| CHEMBL2137046 | 10.85 | Ki | 0.014 | Preclinical |
| CHEMBL135 | 10.82 | Ki | 0.015 | Approved |
| CHEMBL411 | 10.7 | EC50 | 0.02 | Approved |
| CHEMBL1627464 | 10.6 | Ki | 0.025 | Preclinical |
| CHEMBL4782490 | 10.54 | EC50 | 0.029 | Preclinical |
| CHEMBL135 | 10.34 | IC50 | 0.046 | Approved |
| CHEMBL128227 | 10.32 | Ki | 0.048 | Preclinical |
| CHEMBL4753115 | 10.3 | EC50 | 0.05 | Preclinical |
| CHEMBL315474 | 10.22 | Ki | 0.06 | Preclinical |