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Target Snapshot

CHEMBL2420 Target Snapshot

Carbonic anhydrase-related protein 11 · SINGLE PROTEIN · Homo sapiens

20Compounds
2Assays
1Approved Drugs
14.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O75493. Use UniProt O75493 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O75493 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase-related protein 11 as ChEMBL target CHEMBL2420, mapped to UniProt O75493. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase-related protein 11
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2420
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O75493
Carbonic anhydrase-related protein 11
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase-related protein 11 is the right protein anchor across sources, using UniProt O75493 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase-related protein 11
UniProt AccessionO75493
Component TypeProtein
Sequence Length328 aa

Carbonic anhydrase-related protein 11

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase-related protein 11, mapped to UniProt O75493. Sequence length is 328 aa.

Mapped IDO75493
Review nameCarbonic anhydrase-related protein 11
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KI14.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4080604 8.92 Ki 1.2 Preclinical
CHEMBL4097126 8.39 Ki 4.1 Preclinical
CHEMBL4081547 8.35 Ki 4.5 Preclinical
CHEMBL20 8.24 Ki 5.7 Approved
CHEMBL4061260 8.24 Ki 5.8 Preclinical
CHEMBL4070963 8.24 Ki 5.7 Preclinical
CHEMBL4069928 8.23 Ki 5.9 Preclinical
CHEMBL4099555 8.22 Ki 6.0 Preclinical
CHEMBL4089415 8.21 Ki 6.1 Preclinical
CHEMBL4064015 8.2 Ki 6.3 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
3
7.0
0
7.5
10
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

2
Total Assays
14
Tested Compounds
1
Assay Types
Binding — 2 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 14 8.1
single protein format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine