Use UniProt P08185 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2421 Target Snapshot
Corticosteroid-binding globulin · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P08185. Use UniProt P08185 as the stable identity anchor, then attach disease evidence before program review.
Corticosteroid-binding globulin
Review this target as Corticosteroid-binding globulin, mapped to UniProt P08185. Sequence length is 405 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Corticosteroid-binding globulin as ChEMBL target CHEMBL2421, mapped to UniProt P08185. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Corticosteroid-binding globulin is the right protein anchor across sources, using UniProt P08185 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | Corticosteroid-binding globulin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08185 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Corticosteroid-binding globulin |
| UniProt Accession | P08185 |
| Component Type | Protein |
| Sequence Length | 405 aa |
Corticosteroid-binding globulin
How to read this target
Review this target as Corticosteroid-binding globulin, mapped to UniProt P08185. Sequence length is 405 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL110739 | 7.88 | Ki | 13.18 | Clinical |
| CHEMBL389621 | 7.88 | Ki | 13.18 | Approved |
| CHEMBL253144 | 7.88 | Ki | 13.18 | Clinical |
| CHEMBL1062 | 7.74 | Ki | 18.2 | Preclinical |
| CHEMBL432825 | 7.69 | Ki | 20.42 | Preclinical |
| CHEMBL1498 | 7.65 | Ki | 22.39 | Preclinical |
| CHEMBL1091 | 7.55 | Ki | 28.18 | Approved |
| CHEMBL131 | 7.51 | Ki | 30.9 | Approved |
| CHEMBL103 | 7.38 | Ki | 41.69 | Approved |
| CHEMBL433198 | 7.12 | Ki | 75.86 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 14 assays, 30 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 14 | 30 | 6.4 |