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Target Snapshot

CHEMBL2429709 Target Snapshot

Protein mono-ADP-ribosyltransferase PARP12 · SINGLE PROTEIN · Homo sapiens

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62Compounds
34Assays
3Approved Drugs
59.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9H0J9. Use UniProt Q9H0J9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9H0J9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein mono-ADP-ribosyltransferase PARP12 as ChEMBL target CHEMBL2429709, mapped to UniProt Q9H0J9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein mono-ADP-ribosyltransferase PARP12
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2429709
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9H0J9
Protein mono-ADP-ribosyltransferase PARP12
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein mono-ADP-ribosyltransferase PARP12 is the right protein anchor across sources, using UniProt Q9H0J9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProtein mono-ADP-ribosyltransferase PARP12
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9H0J9
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein mono-ADP-ribosyltransferase PARP12
UniProt AccessionQ9H0J9
Component TypeProtein
Sequence Length701 aa

Protein mono-ADP-ribosyltransferase PARP12

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Protein mono-ADP-ribosyltransferase PARP12, mapped to UniProt Q9H0J9. Sequence length is 701 aa.

Mapped IDQ9H0J9
Review nameProtein mono-ADP-ribosyltransferase PARP12
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
1
Phase I
Assay Mix

Activity Type Distribution

IC5056.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5402698 7.85 IC50 14.1 Preclinical
CHEMBL5095043 7.6 IC50 25.0 Preclinical
CHEMBL1094636 7.1 IC50 79.0 Approved
CHEMBL5404785 6.8 IC50 158.49 Preclinical
CHEMBL372303 6.65 IC50 223.87 Preclinical
CHEMBL5639789 6.44 IC50 360.0 Preclinical
CHEMBL5176874 6.43 IC50 371.0 Preclinical
CHEMBL5395820 6.34 IC50 453.0 Preclinical
CHEMBL5571636 6.18 IC50 664.0 Preclinical
CHEMBL521686 6.16 IC50 690.0 Approved
Distribution

pChEMBL Value Distribution

5
5.0
3
5.5
6
6.0
4
6.5
1
7.0
3
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIRAPARIB
CHEMBL1094636
Approved 2017
Properties Compare Identifier
OLAPARIB
CHEMBL521686
Approved 2014
Properties Compare Identifier
Assay Landscape

Assay Landscape

34
Total Assays
21
Tested Compounds
1
Assay Types
Binding — 34 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 22 9 6.3
assay format 6 9 5.5
cell-based format 6 3 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine