Orexin/Hypocretin receptor type 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P58307. Use UniProt P58307 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P58307 as the stable identity anchor, then attach disease evidence before program review.
Orexin/Hypocretin receptor type 1
Review this target as Orexin/Hypocretin receptor type 1, mapped to UniProt P58307. Sequence length is 416 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Orexin/Hypocretin receptor type 1 as ChEMBL target CHEMBL2434819, mapped to UniProt P58307. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Orexin/Hypocretin receptor type 1 is the right protein anchor across sources, using UniProt P58307 as the stable mapping.
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| Preferred Name | Orexin/Hypocretin receptor type 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P58307 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Orexin/Hypocretin receptor type 1 |
| UniProt Accession | P58307 |
| Component Type | Protein |
| Sequence Length | 416 aa |
Orexin/Hypocretin receptor type 1
Review this target as Orexin/Hypocretin receptor type 1, mapped to UniProt P58307. Sequence length is 416 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1083659 | 8.77 | Ki | 1.698 | Approved |
| CHEMBL5417451 | 6.81 | EC50 | 154.0 | Preclinical |
| CHEMBL5203887 | 6.76 | EC50 | 174.0 | Preclinical |
| CHEMBL2435402 | 6.34 | Ki | 457.09 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 4 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |