Myeloperoxidase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Myeloperoxidase shows late clinical disease relevance led by multiple system atrophy. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P05164. Start with multiple system atrophy, then reuse UniProt P05164 as the stable protein anchor across project notes and exports.
Start with multiple system atrophy, then reuse UniProt P05164 as the stable protein anchor across project notes and exports.
Myeloperoxidase shows late clinical disease relevance led by multiple system atrophy. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with multiple system atrophy because it currently carries late clinical support. Linked drugs include VERDIPERSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMyeloperoxidase
Review this target as Myeloperoxidase, mapped to UniProt P05164. Sequence length is 745 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Myeloperoxidase as ChEMBL target CHEMBL2439, mapped to UniProt P05164. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Myeloperoxidase is the right protein anchor across sources, using UniProt P05164 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why multiple system atrophy is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Myeloperoxidase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P05164 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Myeloperoxidase |
| UniProt Accession | P05164 |
| Component Type | Protein |
| Sequence Length | 745 aa |
Myeloperoxidase
Review this target as Myeloperoxidase, mapped to UniProt P05164. Sequence length is 745 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Myeloperoxidase shows late clinical disease relevance led by multiple system atrophy. 3 more disease programs remain visible in the same review block.
Start review with multiple system atrophy because it currently carries late clinical support. Linked drugs include VERDIPERSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4747269 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4790231 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5639106 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5197968 | 8.9 | IC50 | 1.259 | Preclinical |
| CHEMBL5095218 | 8.82 | IC50 | 1.5 | Clinical |
| CHEMBL5646914 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5646667 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4763667 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5641842 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4752248 | 8.54 | IC50 | 2.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 122 | 568 | 6.7 |
| assay format | 19 | 47 | 7.5 |
| tissue-based format | 8 | 37 | 6.2 |
| cell-based format | 6 | 15 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 6 | 5 | 4.3 |
| assay format | 3 | 1 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 0 | — |