Polyunsaturated fatty acid lipoxygenase ALOX15B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O15296. Use UniProt O15296 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15296 as the stable identity anchor, then attach disease evidence before program review.
Polyunsaturated fatty acid lipoxygenase ALOX15B
Review this target as Polyunsaturated fatty acid lipoxygenase ALOX15B, mapped to UniProt O15296. Sequence length is 676 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polyunsaturated fatty acid lipoxygenase ALOX15B as ChEMBL target CHEMBL2457, mapped to UniProt O15296. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Polyunsaturated fatty acid lipoxygenase ALOX15B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15296 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyunsaturated fatty acid lipoxygenase ALOX15B |
| UniProt Accession | O15296 |
| Component Type | Protein |
| Sequence Length | 676 aa |
Polyunsaturated fatty acid lipoxygenase ALOX15B
Review this target as Polyunsaturated fatty acid lipoxygenase ALOX15B, mapped to UniProt O15296. Sequence length is 676 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL235920 | 7.29 | IC50 | 51.0 | Preclinical |
| CHEMBL399821 | 6.83 | IC50 | 147.0 | Preclinical |
| CHEMBL1390514 | 6.47 | IC50 | 340.0 | Preclinical |
| CHEMBL392977 | 6.4 | IC50 | 402.0 | Preclinical |
| CHEMBL391659 | 6.36 | IC50 | 433.0 | Preclinical |
| CHEMBL1520238 | 6.28 | IC50 | 530.0 | Preclinical |
| CHEMBL1452107 | 6.22 | EC50 | 600.0 | Preclinical |
| CHEMBL1390514 | 6.12 | EC50 | 750.0 | Preclinical |
| CHEMBL1352020 | 6.06 | IC50 | 870.0 | Preclinical |
| CHEMBL1352020 | 5.89 | EC50 | 1300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 14 | 10 | 5.3 |
| cell-based format | 4 | 9 | 6.1 |
| assay format | 2 | 2 | 4.9 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |