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Target Snapshot

CHEMBL2470 Target Snapshot

Cannabinoid receptor 2 · SINGLE PROTEIN · Rattus norvegicus

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607Compounds
72Assays
0Approved Drugs
556.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9QZN9. Use UniProt Q9QZN9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9QZN9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cannabinoid receptor 2 as ChEMBL target CHEMBL2470, mapped to UniProt Q9QZN9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cannabinoid receptor 2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2470
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9QZN9
Cannabinoid receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cannabinoid receptor 2 is the right protein anchor across sources, using UniProt Q9QZN9 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCannabinoid receptor 2
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ9QZN9
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCannabinoid receptor 2
UniProt AccessionQ9QZN9
Component TypeProtein
Sequence Length360 aa

Cannabinoid receptor 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cannabinoid receptor 2, mapped to UniProt Q9QZN9. Sequence length is 360 aa.

Mapped IDQ9QZN9
Review nameCannabinoid receptor 2
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

4
Phase II
Assay Mix

Activity Type Distribution

IC5025.0
KI388.0
EC50143.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL584742 10.15 EC50 0.07 Preclinical
CHEMBL499324 9.89 EC50 0.13 Preclinical
CHEMBL3647318 9.82 Ki 0.15 Preclinical
CHEMBL271158 9.77 EC50 0.17 Preclinical
CHEMBL5198892 9.66 IC50 0.22 Preclinical
CHEMBL1076680 9.57 Ki 0.27 Preclinical
CHEMBL501472 9.57 EC50 0.27 Preclinical
CHEMBL3650103 9.52 Ki 0.3 Preclinical
CHEMBL3686293 9.52 Ki 0.3 Preclinical
CHEMBL3686304 9.52 Ki 0.3 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
14
5.5
32
6.0
36
6.5
97
7.0
96
7.5
101
8.0
59
8.5
30
9.0
10
9.5
pChEMBL
Assay Landscape

Assay Landscape

72
Total Assays
357
Tested Compounds
2
Assay Types
Binding — 42 assays, 357 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 138 7.3
cell-based format 10 202 8.1
cell membrane format 8 5 6.3
tissue-based format 8 3 7.1
assay format 3 9 7.1
Functional — 30 assays, 120 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 86 7.8
assay format 5 21 7.4
cell membrane format 3 13 7.3
tissue-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine