Presenilin-1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P49768. Use UniProt P49768 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49768 as the stable identity anchor, then attach disease evidence before program review.
Presenilin-1
Review this target as Presenilin-1, mapped to UniProt P49768. Sequence length is 467 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Presenilin-1 as ChEMBL target CHEMBL2473, mapped to UniProt P49768. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Presenilin-1 is the right protein anchor across sources, using UniProt P49768 as the stable mapping.
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| Preferred Name | Presenilin-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P49768 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Presenilin-1 |
| UniProt Accession | P49768 |
| Component Type | Protein |
| Sequence Length | 467 aa |
Presenilin-1
Review this target as Presenilin-1, mapped to UniProt P49768. Sequence length is 467 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL392068 | 9.94 | EC50 | 0.114 | Preclinical |
| CHEMBL1091513 | 9.19 | IC50 | 0.65 | Preclinical |
| CHEMBL2159511 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL2159510 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3942982 | 8.48 | IC50 | 3.34 | Preclinical |
| CHEMBL3893460 | 8.26 | IC50 | 5.48 | Preclinical |
| CHEMBL3890783 | 8.24 | IC50 | 5.78 | Preclinical |
| CHEMBL2159509 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3951810 | 8.11 | IC50 | 7.84 | Preclinical |
| CHEMBL2159689 | 8.1 | IC50 | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 74 | 117 | 6.1 |
| assay format | 3 | 10 | 7.7 |
| single protein format | 2 | 1 | 9.2 |