Alpha-amylase 1A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P0DUB6. Use UniProt P0DUB6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0DUB6 as the stable identity anchor, then attach disease evidence before program review.
Alpha-amylase 1A
Review this target as Alpha-amylase 1A, mapped to UniProt P0DUB6. Sequence length is 511 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-amylase 1A as ChEMBL target CHEMBL2478, mapped to UniProt P0DUB6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Alpha-amylase 1A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P0DUB6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-amylase 1A |
| UniProt Accession | P0DUB6 |
| Component Type | Protein |
| Sequence Length | 511 aa |
Alpha-amylase 1A
Review this target as Alpha-amylase 1A, mapped to UniProt P0DUB6. Sequence length is 511 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3618492 | 6.72 | Ki | 190.0 | Preclinical |
| CHEMBL404271 | 6.37 | IC50 | 430.0 | Approved |
| CHEMBL3618490 | 6.16 | Ki | 700.0 | Preclinical |
| CHEMBL5597515 | 6.01 | IC50 | 980.0 | Preclinical |
| CHEMBL5597113 | 5.81 | IC50 | 1550.0 | Preclinical |
| CHEMBL5597693 | 5.8 | IC50 | 1590.0 | Preclinical |
| CHEMBL382408 | 5.63 | IC50 | 2350.0 | Preclinical |
| CHEMBL382408 | 5.58 | Ki | 2600.0 | Preclinical |
| CHEMBL5596134 | 5.23 | IC50 | 5940.0 | Preclinical |
| CHEMBL5596261 | 5.08 | IC50 | 8370.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 44 | 4.5 |