Proto-oncogene tyrosine-protein kinase LCK · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P06240. Use UniProt P06240 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06240 as the stable identity anchor, then attach disease evidence before program review.
Proto-oncogene tyrosine-protein kinase LCK
Review this target as Proto-oncogene tyrosine-protein kinase LCK, mapped to UniProt P06240. Sequence length is 509 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Proto-oncogene tyrosine-protein kinase LCK as ChEMBL target CHEMBL2480, mapped to UniProt P06240. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Proto-oncogene tyrosine-protein kinase LCK |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P06240 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Proto-oncogene tyrosine-protein kinase LCK |
| UniProt Accession | P06240 |
| Component Type | Protein |
| Sequence Length | 509 aa |
Proto-oncogene tyrosine-protein kinase LCK
Review this target as Proto-oncogene tyrosine-protein kinase LCK, mapped to UniProt P06240. Sequence length is 509 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5416410 | 10.19 | Ki | 0.064 | Approved |
| CHEMBL364623 | 9.89 | Ki | 0.13 | Preclinical |
| CHEMBL249317 | 8.07 | IC50 | 8.5 | Preclinical |
| CHEMBL398422 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL249097 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL248676 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL406845 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL398894 | 7.48 | IC50 | 33.0 | Preclinical |
| CHEMBL306380 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL250324 | 7.4 | IC50 | 40.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 24 | 70 | 6.2 |
| cell-based format | 2 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 7.1 |
| organism-based format | 1 | 0 | — |