5-hydroxytryptamine receptor 2A · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-14Protein identity stays anchored to UniProt P50129. Use UniProt P50129 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P50129 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A, mapped to UniProt P50129. Sequence length is 470 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 2A as ChEMBL target CHEMBL2490, mapped to UniProt P50129. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 2A is the right protein anchor across sources, using UniProt P50129 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 2A |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | P50129 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2A |
| UniProt Accession | P50129 |
| Component Type | Protein |
| Sequence Length | 470 aa |
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A, mapped to UniProt P50129. Sequence length is 470 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL201170 | 9.19 | Kd | 0.6457 | Preclinical |
| CHEMBL203637 | 9.05 | Kd | 0.8913 | Preclinical |
| CHEMBL51 | 8.88 | Kd | 1.318 | Clinical |
| CHEMBL201525 | 8.7 | Kd | 1.995 | Preclinical |
| CHEMBL380330 | 8.69 | Kd | 2.042 | Preclinical |
| CHEMBL231070 | 8.67 | Kd | 2.138 | Preclinical |
| CHEMBL276778 | 8.47 | Kd | 3.388 | Preclinical |
| CHEMBL216439 | 8.42 | Kd | 3.802 | Preclinical |
| CHEMBL508399 | 8.4 | Kd | 3.981 | Preclinical |
| CHEMBL389357 | 8.24 | Kd | 5.754 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 9 | 54 | 5.8 |
| single protein format | 3 | 16 | 6.3 |
| assay format | 1 | 9 | 6.0 |
| tissue-based format | 1 | 12 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 11 | 8.5 |