P2X purinoceptor 7 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q64663. Use UniProt Q64663 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q64663 as the stable identity anchor, then attach disease evidence before program review.
P2X purinoceptor 7
Review this target as P2X purinoceptor 7, mapped to UniProt Q64663. Sequence length is 595 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats P2X purinoceptor 7 as ChEMBL target CHEMBL2496, mapped to UniProt Q64663. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | P2X purinoceptor 7 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q64663 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | P2X purinoceptor 7 |
| UniProt Accession | Q64663 |
| Component Type | Protein |
| Sequence Length | 595 aa |
P2X purinoceptor 7
Review this target as P2X purinoceptor 7, mapped to UniProt Q64663. Sequence length is 595 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3663257 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL3663316 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL2338351 | 9.1 | Ki | 0.7943 | Preclinical |
| CHEMBL3663252 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL3674107 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL3891612 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3663242 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL3919664 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL3697516 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL6020881 | 8.89 | IC50 | 1.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 33 | 624 | 6.7 |
| single protein format | 24 | 57 | 6.8 |
| assay format | 10 | 461 | 6.9 |
| cell membrane format | 3 | 11 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 10 | 91 | 6.5 |
| cell-based format | 9 | 180 | 6.9 |
| tissue-based format | 1 | 1 | 6.9 |