Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P32871. Use UniProt P32871 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P32871 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mapped to UniProt P32871. Sequence length is 1068 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform as ChEMBL target CHEMBL2498, mapped to UniProt P32871. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P32871 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| UniProt Accession | P32871 |
| Component Type | Protein |
| Sequence Length | 1068 aa |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mapped to UniProt P32871. Sequence length is 1068 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3589372 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL555968 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL3589370 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL556399 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3589371 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL536070 | 9.11 | IC50 | 0.77 | Preclinical |
| CHEMBL3589324 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL3589377 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL223071 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL3589379 | 8.72 | IC50 | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 33 | 7.7 |
| assay format | 1 | 1 | 5.2 |
| single protein format | 1 | 12 | 7.4 |