Thiopurine S-methyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P51580. Use UniProt P51580 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51580 as the stable identity anchor, then attach disease evidence before program review.
Thiopurine S-methyltransferase
Review this target as Thiopurine S-methyltransferase, mapped to UniProt P51580. Sequence length is 245 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thiopurine S-methyltransferase as ChEMBL target CHEMBL2500, mapped to UniProt P51580. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Thiopurine S-methyltransferase is the right protein anchor across sources, using UniProt P51580 as the stable mapping.
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| Preferred Name | Thiopurine S-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51580 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thiopurine S-methyltransferase |
| UniProt Accession | P51580 |
| Component Type | Protein |
| Sequence Length | 245 aa |
Thiopurine S-methyltransferase
Review this target as Thiopurine S-methyltransferase, mapped to UniProt P51580. Sequence length is 245 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL415511 | 6.13 | IC50 | 741.31 | Preclinical |
| CHEMBL4591248 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL89875 | 5.92 | IC50 | 1202.26 | Preclinical |
| CHEMBL327180 | 5.59 | IC50 | 2570.4 | Preclinical |
| CHEMBL89826 | 5.52 | IC50 | 3019.95 | Preclinical |
| CHEMBL90106 | 5.05 | IC50 | 8912.51 | Preclinical |
| CHEMBL1214186 | 5.0 | Kd | 10000.0 | Clinical |
| CHEMBL85234 | 4.7 | IC50 | 19952.62 | Preclinical |
| CHEMBL118280 | 4.55 | IC50 | 28183.83 | Preclinical |
| CHEMBL118239 | 4.48 | IC50 | 33113.11 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 1 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 28 | 5.0 |
| tissue-based format | 1 | 0 | — |