Adenosine receptor A2a · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Adenosine receptor A2a shows approved-linked disease relevance led by Parkinson disease. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P29274. Start with Parkinson disease, then reuse UniProt P29274 as the stable protein anchor across project notes and exports.
Start with Parkinson disease, then reuse UniProt P29274 as the stable protein anchor across project notes and exports.
Adenosine receptor A2a shows approved-linked disease relevance led by Parkinson disease. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.
Start review with Parkinson disease because it currently carries approved-linked support. Linked drugs include CIFORADENANT, ISTRADEFYLLINE, PBF-509, PRELADENANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAdenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt P29274. Sequence length is 412 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenosine receptor A2a as ChEMBL target CHEMBL251, mapped to UniProt P29274. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Adenosine receptor A2a is the right protein anchor across sources, using UniProt P29274 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Parkinson disease is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Adenosine receptor A2a |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P29274 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A2a |
| UniProt Accession | P29274 |
| Component Type | Protein |
| Sequence Length | 412 aa |
Adenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt P29274. Sequence length is 412 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Adenosine receptor A2a shows approved-linked disease relevance led by Parkinson disease. 5 more disease programs remain visible in the same review block.
Start review with Parkinson disease because it currently carries approved-linked support. Linked drugs include CIFORADENANT, ISTRADEFYLLINE, PBF-509, PRELADENANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2419139 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4167125 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL1092271 | 10.8 | Ki | 0.016 | Preclinical |
| CHEMBL2419146 | 10.57 | Ki | 0.027 | Preclinical |
| CHEMBL336608 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL2419147 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL5182250 | 10.44 | IC50 | 0.036 | Preclinical |
| CHEMBL4161758 | 10.44 | IC50 | 0.036 | Preclinical |
| CHEMBL1090578 | 10.42 | Ki | 0.038 | Preclinical |
| CHEMBL4172399 | 10.4 | IC50 | 0.04 | Preclinical |