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Target Snapshot

CHEMBL2514 Target Snapshot

Neurotensin receptor type 2 · SINGLE PROTEIN · Homo sapiens

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269Compounds
29Assays
0Approved Drugs
234.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O95665. Use UniProt O95665 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O95665 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neurotensin receptor type 2 as ChEMBL target CHEMBL2514, mapped to UniProt O95665. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neurotensin receptor type 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2514
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O95665
Neurotensin receptor type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neurotensin receptor type 2 is the right protein anchor across sources, using UniProt O95665 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeurotensin receptor type 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO95665
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeurotensin receptor type 2
UniProt AccessionO95665
Component TypeProtein
Sequence Length410 aa

Neurotensin receptor type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neurotensin receptor type 2, mapped to UniProt O95665. Sequence length is 410 aa.

Mapped IDO95665
Review nameNeurotensin receptor type 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC5032.0
KI146.0
EC5053.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4798887 10.52 Ki 0.03 Preclinical
CHEMBL4789659 10.05 Ki 0.09 Preclinical
CHEMBL4742999 9.96 Ki 0.11 Preclinical
CHEMBL4758754 9.8 Ki 0.16 Preclinical
CHEMBL337721 9.64 IC50 0.23 Preclinical
CHEMBL3622802 9.59 IC50 0.26 Preclinical
CHEMBL4744531 9.54 Ki 0.29 Preclinical
CHEMBL336836 9.52 IC50 0.3 Preclinical
CHEMBL4749016 9.49 Ki 0.32 Preclinical
CHEMBL4745899 9.48 Ki 0.33 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
13
5.5
22
6.0
9
6.5
22
7.0
19
7.5
36
8.0
19
8.5
16
9.0
6
9.5
pChEMBL
Assay Landscape

Assay Landscape

29
Total Assays
155
Tested Compounds
2
Assay Types
Binding — 27 assays, 155 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 95 7.5
single protein format 11 29 8.3
cell membrane format 2 31 7.2
Functional — 2 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 5 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine