Endothelin-1 receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Endothelin-1 receptor shows approved-linked disease relevance led by IGA glomerulonephritis. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P25101. Start with IGA glomerulonephritis, then reuse UniProt P25101 as the stable protein anchor across project notes and exports.
Start with IGA glomerulonephritis, then reuse UniProt P25101 as the stable protein anchor across project notes and exports.
Endothelin-1 receptor shows approved-linked disease relevance led by IGA glomerulonephritis. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with IGA glomerulonephritis because it currently carries approved-linked support. Linked drugs include SPARSENTAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEndothelin-1 receptor
Review this target as Endothelin-1 receptor, mapped to UniProt P25101. Sequence length is 427 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Endothelin-1 receptor as ChEMBL target CHEMBL252, mapped to UniProt P25101. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Endothelin-1 receptor is the right protein anchor across sources, using UniProt P25101 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why IGA glomerulonephritis is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Endothelin-1 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P25101 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endothelin-1 receptor |
| UniProt Accession | P25101 |
| Component Type | Protein |
| Sequence Length | 427 aa |
Endothelin-1 receptor
Review this target as Endothelin-1 receptor, mapped to UniProt P25101. Sequence length is 427 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Endothelin-1 receptor shows approved-linked disease relevance led by IGA glomerulonephritis. 5 more disease programs remain visible in the same review block.
Start review with IGA glomerulonephritis because it currently carries approved-linked support. Linked drugs include SPARSENTAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL277447 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL440780 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL274489 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL411925 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL289634 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL286621 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL432856 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL287683 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL1627022 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL60058 | 10.7 | IC50 | 0.02 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 209 | 560 | 7.5 |
| cell-based format | 80 | 774 | 7.5 |
| assay format | 13 | 83 | 6.5 |
| cell membrane format | 8 | 13 | 7.4 |
| tissue-based format | 7 | 22 | 6.5 |
| organism-based format | 1 | 1 | 8.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 29 | 131 | 7.7 |
| assay format | 26 | 101 | 7.6 |
| tissue-based format | 6 | 14 | 5.3 |
| cell membrane format | 1 | 3 | 8.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |