Alpha-galactosidase A · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Alpha-galactosidase A shows approved-linked disease relevance led by Fabry disease. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P06280. Start with Fabry disease, then reuse UniProt P06280 as the stable protein anchor across project notes and exports.
Start with Fabry disease, then reuse UniProt P06280 as the stable protein anchor across project notes and exports.
Alpha-galactosidase A shows approved-linked disease relevance led by Fabry disease. 2 linked drugs remain visible in the same block.
Start review with Fabry disease because it currently carries approved-linked support. Linked drugs include MIGALASTAT, MIGALASTAT HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAlpha-galactosidase A
Review this target as Alpha-galactosidase A, mapped to UniProt P06280. Sequence length is 429 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-galactosidase A as ChEMBL target CHEMBL2524, mapped to UniProt P06280. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Alpha-galactosidase A is the right protein anchor across sources, using UniProt P06280 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Fabry disease is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Alpha-galactosidase A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P06280 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-galactosidase A |
| UniProt Accession | P06280 |
| Component Type | Protein |
| Sequence Length | 429 aa |
Alpha-galactosidase A
Review this target as Alpha-galactosidase A, mapped to UniProt P06280. Sequence length is 429 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Alpha-galactosidase A shows approved-linked disease relevance led by Fabry disease.
Start review with Fabry disease because it currently carries approved-linked support. Linked drugs include MIGALASTAT, MIGALASTAT HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL110458 | 7.89 | IC50 | 13.0 | Approved |
| CHEMBL3350086 | 7.28 | IC50 | 53.0 | Preclinical |
| CHEMBL4792854 | 6.7 | Ki | 200.0 | Preclinical |
| CHEMBL469844 | 6.3 | Ki | 500.0 | Preclinical |
| CHEMBL469844 | 6.16 | IC50 | 690.0 | Preclinical |
| CHEMBL4069007 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL4168689 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL4792854 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL4793095 | 5.82 | Ki | 1500.0 | Preclinical |
| CHEMBL4081664 | 5.7 | Ki | 2000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 76 | 51 | 5.4 |
| cell-based format | 22 | 0 | — |
| tissue-based format | 4 | 0 | — |
| assay format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 10 | 0 | — |