C-1-tetrahydrofolate synthase, cytoplasmic · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P11586. Use UniProt P11586 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11586 as the stable identity anchor, then attach disease evidence before program review.
C-1-tetrahydrofolate synthase, cytoplasmic
Review this target as C-1-tetrahydrofolate synthase, cytoplasmic, mapped to UniProt P11586. Sequence length is 935 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats C-1-tetrahydrofolate synthase, cytoplasmic as ChEMBL target CHEMBL2541, mapped to UniProt P11586. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | C-1-tetrahydrofolate synthase, cytoplasmic |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11586 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | C-1-tetrahydrofolate synthase, cytoplasmic |
| UniProt Accession | P11586 |
| Component Type | Protein |
| Sequence Length | 935 aa |
C-1-tetrahydrofolate synthase, cytoplasmic
Review this target as C-1-tetrahydrofolate synthase, cytoplasmic, mapped to UniProt P11586. Sequence length is 935 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5653589 | 7.06 | Kd | 87.14 | Preclinical |
| CHEMBL1233930 | 7.02 | IC50 | 96.0 | Preclinical |
| CHEMBL4463968 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL4470947 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL4483030 | 5.54 | IC50 | 2900.0 | Preclinical |
| CHEMBL4542665 | 5.38 | IC50 | 4200.0 | Preclinical |
| CHEMBL4584730 | 5.31 | IC50 | 4900.0 | Preclinical |
| CHEMBL4441993 | 5.3 | IC50 | 5000.0 | Preclinical |
| CHEMBL4534641 | 5.28 | IC50 | 5200.0 | Preclinical |
| CHEMBL4441792 | 5.27 | IC50 | 5400.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 19 | 18 | 5.2 |
| assay format | 8 | 1 | 7.0 |
| cell-based format | 1 | 0 | — |