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Target Snapshot

CHEMBL2548 Target Snapshot

Neuropeptide Y receptor type 5 · SINGLE PROTEIN · Rattus norvegicus

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68Compounds
16Assays
0Approved Drugs
66.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q63634. Use UniProt Q63634 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q63634 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neuropeptide Y receptor type 5 as ChEMBL target CHEMBL2548, mapped to UniProt Q63634. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neuropeptide Y receptor type 5
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2548
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q63634
Neuropeptide Y receptor type 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neuropeptide Y receptor type 5 is the right protein anchor across sources, using UniProt Q63634 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeuropeptide Y receptor type 5
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ63634
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeuropeptide Y receptor type 5
UniProt AccessionQ63634
Component TypeProtein
Sequence Length445 aa

Neuropeptide Y receptor type 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neuropeptide Y receptor type 5, mapped to UniProt Q63634. Sequence length is 445 aa.

Mapped IDQ63634
Review nameNeuropeptide Y receptor type 5
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC5062.0
KI4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL522388 9.17 IC50 0.67 Preclinical
CHEMBL524085 8.89 IC50 1.3 Preclinical
CHEMBL17645 8.85 IC50 1.4 Preclinical
CHEMBL1836317 8.85 Ki 1.4 Preclinical
CHEMBL161724 8.77 Ki 1.7 Preclinical
CHEMBL491930 8.77 IC50 1.7 Preclinical
CHEMBL594163 8.77 IC50 1.7 Preclinical
CHEMBL595573 8.68 IC50 2.1 Clinical
CHEMBL595790 8.68 IC50 2.1 Preclinical
CHEMBL595560 8.66 IC50 2.2 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
7
6.5
9
7.0
9
7.5
11
8.0
12
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

16
Total Assays
49
Tested Compounds
2
Assay Types
Binding — 10 assays, 49 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 14 8.7
cell-based format 2 32 7.2
assay format 1 3 8.4
Functional — 6 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 3 8.3
cell-based format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine