Death-associated protein kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P53355. Use UniProt P53355 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P53355 as the stable identity anchor, then attach disease evidence before program review.
Death-associated protein kinase 1
Review this target as Death-associated protein kinase 1, mapped to UniProt P53355. Sequence length is 1430 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Death-associated protein kinase 1 as ChEMBL target CHEMBL2558, mapped to UniProt P53355. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Death-associated protein kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P53355 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Death-associated protein kinase 1 |
| UniProt Accession | P53355 |
| Component Type | Protein |
| Sequence Length | 1430 aa |
Death-associated protein kinase 1
Review this target as Death-associated protein kinase 1, mapped to UniProt P53355. Sequence length is 1430 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL388978 | 8.85 | Kd | 1.4 | Preclinical |
| CHEMBL4568087 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL3735890 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL1287853 | 7.8 | Kd | 16.0 | Approved |
| CHEMBL4764610 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4552628 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL4060481 | 7.27 | Kd | 54.0 | Preclinical |
| CHEMBL475251 | 7.26 | Kd | 55.0 | Clinical |
| CHEMBL4576489 | 7.23 | Kd | 59.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 261 | 65 | 6.2 |
| assay format | 39 | 7 | 6.4 |
| cell-based format | 16 | 3 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 1 | 5.0 |