Histone deacetylase 5 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q9UQL6. Use UniProt Q9UQL6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UQL6 as the stable identity anchor, then attach disease evidence before program review.
Histone deacetylase 5
Review this target as Histone deacetylase 5, mapped to UniProt Q9UQL6. Sequence length is 1122 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 5 as ChEMBL target CHEMBL2563, mapped to UniProt Q9UQL6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histone deacetylase 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UQL6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone deacetylase 5 |
| UniProt Accession | Q9UQL6 |
| Component Type | Protein |
| Sequence Length | 1122 aa |
Histone deacetylase 5
Review this target as Histone deacetylase 5, mapped to UniProt Q9UQL6. Sequence length is 1122 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL483254 | 9.15 | Ki | 0.7 | Approved |
| CHEMBL98 | 9.0 | IC50 | 1.0 | Approved |
| CHEMBL3692689 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL5964075 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL2105763 | 8.68 | Ki | 2.1 | Clinical |
| CHEMBL2312164 | 8.64 | IC50 | 2.31 | Preclinical |
| CHEMBL2414098 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL5891273 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL1830536 | 8.51 | Ki | 3.1 | Preclinical |
| CHEMBL2105763 | 8.43 | IC50 | 3.69 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 235 | 420 | 6.3 |
| cell-based format | 50 | 79 | 5.6 |
| assay format | 25 | 25 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 2 | 4.9 |
| cell-based format | 3 | 5 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 5.5 |