ATP-dependent translocase ABCB1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P21447. Use UniProt P21447 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P21447 as the stable identity anchor, then attach disease evidence before program review.
ATP-dependent translocase ABCB1
Review this target as ATP-dependent translocase ABCB1, mapped to UniProt P21447. Sequence length is 1276 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ATP-dependent translocase ABCB1 as ChEMBL target CHEMBL2573, mapped to UniProt P21447. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether ATP-dependent translocase ABCB1 is the right protein anchor across sources, using UniProt P21447 as the stable mapping.
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| Preferred Name | ATP-dependent translocase ABCB1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P21447 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ATP-dependent translocase ABCB1 |
| UniProt Accession | P21447 |
| Component Type | Protein |
| Sequence Length | 1276 aa |
ATP-dependent translocase ABCB1
Review this target as ATP-dependent translocase ABCB1, mapped to UniProt P21447. Sequence length is 1276 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL164611 | 7.24 | Kd | 57.0 | Preclinical |
| CHEMBL42160 | 6.92 | Kd | 120.0 | Preclinical |
| CHEMBL40638 | 6.75 | Kd | 180.0 | Preclinical |
| CHEMBL64391 | 6.7 | IC50 | 200.0 | Approved |
| CHEMBL29743 | 6.63 | IC50 | 236.0 | Preclinical |
| CHEMBL41122 | 6.6 | Kd | 250.0 | Preclinical |
| CHEMBL490121 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL29631 | 6.53 | IC50 | 294.0 | Preclinical |
| CHEMBL28168 | 6.45 | IC50 | 356.0 | Preclinical |
| CHEMBL40860 | 6.43 | Kd | 370.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 72 | 0 | — |
| cell-based format | 49 | 26 | 5.2 |
| tissue-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 12 | 38 | 5.5 |
| single protein format | 6 | 23 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |