Dihydrofolate reductase · SINGLE PROTEIN · Saccharomyces cerevisiae S288c
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As of 2026-09-14Protein identity stays anchored to UniProt P07807. Use UniProt P07807 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07807 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P07807. Sequence length is 211 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL2576, mapped to UniProt P07807. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dihydrofolate reductase is the right protein anchor across sources, using UniProt P07807 as the stable mapping.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
| UniProt | P07807 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P07807 |
| Component Type | Protein |
| Sequence Length | 211 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P07807. Sequence length is 211 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL7492 | 7.51 | IC50 | 31.0 | Clinical |
| CHEMBL300603 | 7.42 | IC50 | 38.0 | Preclinical |
| CHEMBL54538 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL119 | 7.38 | IC50 | 42.0 | Approved |
| CHEMBL55727 | 7.28 | IC50 | 52.0 | Preclinical |
| CHEMBL57624 | 7.04 | IC50 | 91.0 | Preclinical |
| CHEMBL54792 | 7.01 | IC50 | 97.0 | Preclinical |
| CHEMBL52930 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL53872 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL52688 | 6.89 | IC50 | 130.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| single protein format | 1 | 49 | 6.3 |