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Target Snapshot

CHEMBL2577 Target Snapshot

Sodium/hydrogen exchanger 1 · SINGLE PROTEIN · Rattus norvegicus

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147Compounds
17Assays
2Approved Drugs
161.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P26431. Use UniProt P26431 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P26431 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium/hydrogen exchanger 1 as ChEMBL target CHEMBL2577, mapped to UniProt P26431. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium/hydrogen exchanger 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2577
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P26431
Sodium/hydrogen exchanger 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium/hydrogen exchanger 1 is the right protein anchor across sources, using UniProt P26431 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSodium/hydrogen exchanger 1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP26431
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium/hydrogen exchanger 1
UniProt AccessionP26431
Component TypeProtein
Sequence Length820 aa

Sodium/hydrogen exchanger 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Sodium/hydrogen exchanger 1, mapped to UniProt P26431. Sequence length is 820 aa.

Mapped IDP26431
Review nameSodium/hydrogen exchanger 1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50153.0
KI8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1829127 10.17 IC50 0.068 Preclinical
CHEMBL1829122 10.14 IC50 0.073 Preclinical
CHEMBL1829125 10.08 IC50 0.084 Preclinical
CHEMBL1829126 10.04 IC50 0.091 Preclinical
CHEMBL1829123 9.96 IC50 0.11 Preclinical
CHEMBL1829132 9.51 IC50 0.31 Preclinical
CHEMBL1829128 9.28 IC50 0.53 Preclinical
CHEMBL1829133 9.25 IC50 0.56 Preclinical
CHEMBL1829139 9.17 IC50 0.67 Preclinical
CHEMBL1829138 9.04 IC50 0.92 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
6
5.5
11
6.0
20
6.5
32
7.0
34
7.5
6
8.0
12
8.5
5
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

AMILORIDE
CHEMBL945
Approved 1981
Properties Compare Identifier
Assay Landscape

Assay Landscape

17
Total Assays
91
Tested Compounds
2
Assay Types
Binding — 16 assays, 91 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 11 6.0
assay format 4 51 7.8
cell-free format 3 24 7.8
single protein format 2 5 7.4
Functional — 1 assays, 45 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 45 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine