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Target Snapshot

CHEMBL2579 Target Snapshot

Gamma-aminobutyric acid receptor subunit alpha-6 · SINGLE PROTEIN · Homo sapiens

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23Compounds
5Assays
1Approved Drugs
26.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q16445. Use UniProt Q16445 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q16445 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Gamma-aminobutyric acid receptor subunit alpha-6 as ChEMBL target CHEMBL2579, mapped to UniProt Q16445. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Gamma-aminobutyric acid receptor subunit alpha-6
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2579
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q16445
Gamma-aminobutyric acid receptor subunit alpha-6
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Gamma-aminobutyric acid receptor subunit alpha-6 is the right protein anchor across sources, using UniProt Q16445 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameGamma-aminobutyric acid receptor subunit alpha-6
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ16445
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGamma-aminobutyric acid receptor subunit alpha-6
UniProt AccessionQ16445
Component TypeProtein
Sequence Length453 aa

Gamma-aminobutyric acid receptor subunit alpha-6

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Gamma-aminobutyric acid receptor subunit alpha-6, mapped to UniProt Q16445. Sequence length is 453 aa.

Mapped IDQ16445
Review nameGamma-aminobutyric acid receptor subunit alpha-6
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC501.0
KI25.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL45198 7.18 Ki 65.9 Preclinical
CHEMBL5275690 7.12 Ki 75.0 Preclinical
CHEMBL5290579 6.89 Ki 130.0 Preclinical
CHEMBL407 6.8 Ki 158.49 Approved
CHEMBL5280240 6.32 Ki 480.0 Preclinical
CHEMBL5266498 5.92 Ki 1200.0 Preclinical
CHEMBL49141 5.89 Ki 1300.0 Preclinical
CHEMBL1270038 5.7 Ki 2000.0 Preclinical
CHEMBL454606 5.57 Ki 2700.0 Preclinical
CHEMBL1270841 5.52 Ki 3000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
6
5.5
1
6.0
2
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FLUMAZENIL
CHEMBL407
Approved 1991
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
13
Tested Compounds
1
Assay Types
Binding — 5 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 12 6.0
cell-based format 1 1 7.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine