Review anchor
Neuronal acetylcholine receptor subunit alpha-2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Neuronal acetylcholine receptor subunit alpha-2
CHEMBL2584
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-2 as ChEMBL target CHEMBL2584, mapped to UniProt P12389. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2584
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P12389
Neuronal acetylcholine receptor subunit alpha-2
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Neuronal acetylcholine receptor subunit alpha-2 matters
Neuronal acetylcholine receptor subunit alpha-2 is reviewed as Neuronal acetylcholine receptor subunit alpha-2 (UniProt P12389); the current evidence base includes 1 approved drug, 14 compounds, and 2 assays, with lead potency reaching pChEMBL 10.8.
Protein context
Neuronal acetylcholine receptor subunit alpha-2
Neuronal acetylcholine receptor subunit alpha-2 Sequence length is 511 aa.
Review this target as Neuronal acetylcholine receptor subunit alpha-2, mapped to UniProt P12389. Sequence length is 511 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P12389
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 14 compounds, and 2 assays for this target. The dominant activity type is KI. CHEMBL514372 is the current potency anchor at pChEMBL 10.8.
Use CHEMBL514372 as the tractability anchor when discussing potency (pChEMBL 10.8).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 10.8
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Neuronal acetylcholine receptor subunit alpha-2 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P12389, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
14
Total Compounds
2
Total Assays
1
Approved Drugs
KI: 15.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL514372
|
10.8 | Ki | — |
|
|
No preferred name
CHEMBL563479
|
10.7 | Ki | — |
|
|
No preferred name
CHEMBL6623
|
10.6 | Ki | — |
|
|
No preferred name
CHEMBL563831
|
10.5 | Ki | — |
|
|
No preferred name
CHEMBL476140
|
10.5 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
NICOTINE
CHEMBL3
|
1984 |
Source Header