Macrophage metalloelastase · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P34960. Use UniProt P34960 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P34960 as the stable identity anchor, then attach disease evidence before program review.
Macrophage metalloelastase
Review this target as Macrophage metalloelastase, mapped to UniProt P34960. Sequence length is 473 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Macrophage metalloelastase as ChEMBL target CHEMBL2594, mapped to UniProt P34960. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Macrophage metalloelastase is the right protein anchor across sources, using UniProt P34960 as the stable mapping.
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| Preferred Name | Macrophage metalloelastase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P34960 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Macrophage metalloelastase |
| UniProt Accession | P34960 |
| Component Type | Protein |
| Sequence Length | 473 aa |
Macrophage metalloelastase
Review this target as Macrophage metalloelastase, mapped to UniProt P34960. Sequence length is 473 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL170601 | 8.32 | IC50 | 4.8 | Preclinical |
| CHEMBL85030 | 8.31 | IC50 | 4.9 | Preclinical |
| CHEMBL352526 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL170040 | 8.16 | IC50 | 6.9 | Preclinical |
| CHEMBL514138 | 8.11 | IC50 | 7.7 | Preclinical |
| CHEMBL314064 | 8.02 | IC50 | 9.6 | Preclinical |
| CHEMBL316169 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL83685 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL353451 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL311336 | 7.8 | IC50 | 16.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 18 | 7.7 |