Tyrosine-protein kinase SYK · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Tyrosine-protein kinase SYK shows approved-linked disease relevance led by autoimmune thrombocytopenic purpura. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P43405. Start with autoimmune thrombocytopenic purpura, then reuse UniProt P43405 as the stable protein anchor across project notes and exports.
Start with autoimmune thrombocytopenic purpura, then reuse UniProt P43405 as the stable protein anchor across project notes and exports.
Tyrosine-protein kinase SYK shows approved-linked disease relevance led by autoimmune thrombocytopenic purpura. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with autoimmune thrombocytopenic purpura because it currently carries approved-linked support. Linked drugs include FOSTAMATINIB, FOSTAMATINIB DISODIUM, SOVLEPLENIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosine-protein kinase SYK
Review this target as Tyrosine-protein kinase SYK, mapped to UniProt P43405. Sequence length is 635 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase SYK as ChEMBL target CHEMBL2599, mapped to UniProt P43405. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Tyrosine-protein kinase SYK is the right protein anchor across sources, using UniProt P43405 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why autoimmune thrombocytopenic purpura is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tyrosine-protein kinase SYK |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P43405 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase SYK |
| UniProt Accession | P43405 |
| Component Type | Protein |
| Sequence Length | 635 aa |
Tyrosine-protein kinase SYK
Review this target as Tyrosine-protein kinase SYK, mapped to UniProt P43405. Sequence length is 635 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosine-protein kinase SYK shows approved-linked disease relevance led by autoimmune thrombocytopenic purpura. 5 more disease programs remain visible in the same review block.
Start review with autoimmune thrombocytopenic purpura because it currently carries approved-linked support. Linked drugs include FOSTAMATINIB, FOSTAMATINIB DISODIUM, SOVLEPLENIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3415598 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL4744190 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL3622956 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL5425739 | 10.34 | IC50 | 0.046 | Preclinical |
| CHEMBL4780257 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL3415583 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL5435311 | 10.17 | IC50 | 0.067 | Preclinical |
| CHEMBL5775813 | 10.15 | IC50 | 0.071 | Preclinical |
| CHEMBL5788352 | 10.14 | IC50 | 0.073 | Preclinical |
| CHEMBL5748905 | 10.14 | IC50 | 0.072 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 650 | 4,822 | 7.3 |
| cell-based format | 104 | 322 | 6.8 |
| assay format | 75 | 322 | 6.7 |
| subcellular format | 16 | 16 | 5.9 |
| tissue-based format | 5 | 160 | 6.6 |
| cell membrane format | 1 | 1 | 7.6 |
| cell-free format | 1 | 1 | 5.6 |
| organism-based format | 1 | 213 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 10 | 155 | 6.3 |