Isoleucyl-tRNA synthetase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt O35880. Use UniProt O35880 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35880 as the stable identity anchor, then attach disease evidence before program review.
Isoleucyl tRNA synthetase
Review this target as Isoleucyl-tRNA synthetase, mapped to UniProt O35880. ChEMBL maps the protein component as Isoleucyl tRNA synthetase. Sequence length is 50 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Isoleucyl-tRNA synthetase as ChEMBL target CHEMBL2604, mapped to UniProt O35880. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Isoleucyl-tRNA synthetase is the right protein anchor across sources, using UniProt O35880 as the stable mapping.
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| Preferred Name | Isoleucyl-tRNA synthetase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | O35880 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Isoleucyl tRNA synthetase |
| UniProt Accession | O35880 |
| Component Type | Protein |
| Sequence Length | 50 aa |
Isoleucyl tRNA synthetase
Review this target as Isoleucyl-tRNA synthetase, mapped to UniProt O35880. ChEMBL maps the protein component as Isoleucyl tRNA synthetase. Sequence length is 50 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL74755 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL74395 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL74872 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL309004 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL421500 | 7.17 | IC50 | 68.0 | Preclinical |
| CHEMBL73465 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL305843 | 5.21 | IC50 | 6100.0 | Preclinical |
| CHEMBL74343 | 4.65 | IC50 | 22300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 8 | 7.0 |
| single protein format | 1 | 0 | — |