Adenosine receptor A2a · SINGLE PROTEIN · Cavia porcellus
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As of 2026-09-14Protein identity stays anchored to UniProt P46616. Use UniProt P46616 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P46616 as the stable identity anchor, then attach disease evidence before program review.
Adenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt P46616. Sequence length is 409 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenosine receptor A2a as ChEMBL target CHEMBL2605, mapped to UniProt P46616. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adenosine receptor A2a |
| Target Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
| UniProt | P46616 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A2a |
| UniProt Accession | P46616 |
| Component Type | Protein |
| Sequence Length | 409 aa |
Adenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt P46616. Sequence length is 409 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL139000 | 8.48 | Ki | 3.3 | Preclinical |
| CHEMBL45891 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL261482 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL285819 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL27155 | 7.3 | Ki | 50.0 | Preclinical |
| CHEMBL423239 | 6.96 | Ki | 110.0 | Preclinical |
| CHEMBL27047 | 6.89 | Ki | 130.0 | Preclinical |
| CHEMBL276830 | 6.89 | Ki | 130.0 | Preclinical |
| CHEMBL420705 | 6.89 | Ki | 130.0 | Preclinical |
| CHEMBL52333 | 6.64 | Ki | 230.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 53 | 5.4 |
| single protein format | 1 | 2 | 4.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 2 | 9 | 6.7 |
| cell membrane format | 1 | 16 | 4.8 |
| single protein format | 1 | 3 | 6.0 |