Tryptase beta-1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15661. Use UniProt Q15661 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15661 as the stable identity anchor, then attach disease evidence before program review.
Tryptase alpha/beta-1
Review this target as Tryptase beta-1, mapped to UniProt Q15661. ChEMBL maps the protein component as Tryptase alpha/beta-1. Sequence length is 275 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tryptase beta-1 as ChEMBL target CHEMBL2617, mapped to UniProt Q15661. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Tryptase beta-1 is the right protein anchor across sources, using UniProt Q15661 as the stable mapping.
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| Preferred Name | Tryptase beta-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15661 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tryptase alpha/beta-1 |
| UniProt Accession | Q15661 |
| Component Type | Protein |
| Sequence Length | 275 aa |
Tryptase alpha/beta-1
Review this target as Tryptase beta-1, mapped to UniProt Q15661. ChEMBL maps the protein component as Tryptase alpha/beta-1. Sequence length is 275 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL46809 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL297220 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL310290 | 9.22 | Ki | 0.6 | Preclinical |
| CHEMBL365062 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL211357 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL362874 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL212774 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL380293 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL213928 | 8.74 | Ki | 1.8 | Preclinical |
| CHEMBL377890 | 8.74 | Ki | 1.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 23 | 212 | 7.0 |
| cell-based format | 3 | 15 | 6.3 |
| assay format | 1 | 0 | — |