Liver carboxylesterase 1 · SINGLE PROTEIN · Oryctolagus cuniculus
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As of 2026-09-14Protein identity stays anchored to UniProt P12337. Use UniProt P12337 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P12337 as the stable identity anchor, then attach disease evidence before program review.
Liver carboxylesterase 1
Review this target as Liver carboxylesterase 1, mapped to UniProt P12337. Sequence length is 565 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Liver carboxylesterase 1 as ChEMBL target CHEMBL2623, mapped to UniProt P12337. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Liver carboxylesterase 1 is the right protein anchor across sources, using UniProt P12337 as the stable mapping.
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| Preferred Name | Liver carboxylesterase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
| UniProt | P12337 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Liver carboxylesterase 1 |
| UniProt Accession | P12337 |
| Component Type | Protein |
| Sequence Length | 565 aa |
Liver carboxylesterase 1
Review this target as Liver carboxylesterase 1, mapped to UniProt P12337. Sequence length is 565 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL193228 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL192139 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL192180 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL362996 | 8.68 | Ki | 2.1 | Preclinical |
| CHEMBL191847 | 8.4 | Ki | 4.0 | Preclinical |
| CHEMBL193140 | 8.36 | Ki | 4.4 | Preclinical |
| CHEMBL1812858 | 8.19 | Ki | 6.5 | Preclinical |
| CHEMBL191739 | 8.06 | Ki | 8.7 | Preclinical |
| CHEMBL1812859 | 8.05 | Ki | 9.0 | Preclinical |
| CHEMBL161638 | 8.0 | IC50 | 10.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 49 | 7.2 |
| single protein format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |