Dihydrofolate reductase type 1 · SINGLE PROTEIN · Escherichia coli
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P00382. Use UniProt P00382 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00382 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase type 1
Review this target as Dihydrofolate reductase type 1, mapped to UniProt P00382. Sequence length is 157 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase type 1 as ChEMBL target CHEMBL2627, mapped to UniProt P00382. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Dihydrofolate reductase type 1 is the right protein anchor across sources, using UniProt P00382 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Dihydrofolate reductase type 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
| UniProt | P00382 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase type 1 |
| UniProt Accession | P00382 |
| Component Type | Protein |
| Sequence Length | 157 aa |
Dihydrofolate reductase type 1
Review this target as Dihydrofolate reductase type 1, mapped to UniProt P00382. Sequence length is 157 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL57377 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL418293 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL58455 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL57458 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL300371 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL300385 | 8.51 | IC50 | 3.1 | Preclinical |
| CHEMBL294678 | 8.47 | IC50 | 3.4 | Preclinical |
| CHEMBL59491 | 8.17 | IC50 | 6.8 | Preclinical |
| CHEMBL60647 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL57807 | 8.13 | IC50 | 7.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 47 | 7.5 |