Mitogen-activated protein kinase 10 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Mitogen-activated protein kinase 10 shows late clinical disease relevance led by hearing loss. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P53779. Start with hearing loss, then reuse UniProt P53779 as the stable protein anchor across project notes and exports.
Start with hearing loss, then reuse UniProt P53779 as the stable protein anchor across project notes and exports.
Mitogen-activated protein kinase 10 shows late clinical disease relevance led by hearing loss. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with hearing loss because it currently carries late clinical support. Linked drugs include BRIMAPITIDE, C-TERMINAL ACID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMitogen-activated protein kinase 10
Review this target as Mitogen-activated protein kinase 10, mapped to UniProt P53779. Sequence length is 464 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase 10 as ChEMBL target CHEMBL2637, mapped to UniProt P53779. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Mitogen-activated protein kinase 10 is the right protein anchor across sources, using UniProt P53779 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hearing loss is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Mitogen-activated protein kinase 10 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P53779 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 10 |
| UniProt Accession | P53779 |
| Component Type | Protein |
| Sequence Length | 464 aa |
Mitogen-activated protein kinase 10
Review this target as Mitogen-activated protein kinase 10, mapped to UniProt P53779. Sequence length is 464 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mitogen-activated protein kinase 10 shows late clinical disease relevance led by hearing loss. 3 more disease programs remain visible in the same review block.
Start review with hearing loss because it currently carries late clinical support. Linked drugs include BRIMAPITIDE, C-TERMINAL ACID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL210618 | 10.17 | IC50 | 0.068 | Preclinical |
| CHEMBL4546504 | 9.97 | IC50 | 0.107 | Preclinical |
| CHEMBL3220502 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL3220499 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL3220493 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL3220497 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL3220496 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4077018 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3220498 | 9.51 | IC50 | 0.31 | Preclinical |
| CHEMBL5403678 | 9.42 | IC50 | 0.379 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 546 | 1,498 | 6.3 |
| assay format | 55 | 95 | 6.6 |
| cell-based format | 52 | 44 | 6.3 |
| subcellular format | 13 | 19 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 21 | 7.1 |
| cell-based format | 1 | 1 | 6.0 |
| subcellular format | 1 | 1 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |