Prostaglandin G/H synthase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P22437. Use UniProt P22437 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22437 as the stable identity anchor, then attach disease evidence before program review.
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase 1, mapped to UniProt P22437. Sequence length is 602 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prostaglandin G/H synthase 1 as ChEMBL target CHEMBL2649, mapped to UniProt P22437. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Prostaglandin G/H synthase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P22437 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 1 |
| UniProt Accession | P22437 |
| Component Type | Protein |
| Sequence Length | 602 aa |
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase 1, mapped to UniProt P22437. Sequence length is 602 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL118 | 9.15 | IC50 | 0.7 | Approved |
| CHEMBL6 | 8.7 | IC50 | 2.0 | Approved |
| CHEMBL166863 | 8.52 | IC50 | 3.0 | Clinical |
| CHEMBL469785 | 7.06 | IC50 | 87.0 | Preclinical |
| CHEMBL140804 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL142038 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL143776 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL341878 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL344085 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL441663 | 7.0 | IC50 | 100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 33 | 12 | 5.5 |
| single protein format | 15 | 43 | 5.8 |
| tissue-based format | 1 | 3 | 4.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |