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Evidence Snapshot

Cathepsin K

CHEMBL268 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL268
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cathepsin K as ChEMBL target CHEMBL268, mapped to UniProt P43235. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cathepsin K
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL268
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P43235
Cathepsin K
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Cathepsin K matters

As of 2026-09-13

Cathepsin K is reviewed as Cathepsin K (UniProt P43235); Cathepsin K shows late clinical disease relevance led by osteoporosis. 5 more disease programs remain visible in the same review block.; 2 linked drugs keep this evidence frame grounded.; the current evidence base includes 3 approved drugs, 2936 compounds, and 324 assays, with lead potency reaching pChEMBL 11.0.

Disease context
osteoporosis

Cathepsin K shows late clinical disease relevance led by osteoporosis. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include BALICATIB, ODANACATIB.

Start review with osteoporosis because it currently carries late clinical support. Linked drugs include BALICATIB, ODANACATIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Late clinical 2 linked drugs
Activity base
Portfolio and assay base

ChEMBL currently tracks 3 approved drugs, 2936 compounds, and 324 assays for this target. The dominant activity type is IC50. CHEMBL386506 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL386506 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
3 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Cathepsin K matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P43235, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why osteoporosis is currently treated as late clinical support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2936
Total Compounds
324
Total Assays
3
Approved Drugs
IC50: 2326.0, KI: 926.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL386506
 11.0 IC50 —
No preferred name
CHEMBL414530
 11.0 IC50 —
No preferred name
CHEMBL374890
 11.0 IC50 —
No preferred name
CHEMBL1651354
 11.0 Ki —
No preferred name
CHEMBL449096
 10.9 IC50 —

Approved Drugs

Structure Compound First Approval
BOCEPREVIR
CHEMBL218394
 2011
TELAPREVIR
CHEMBL231813
 2011
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL268