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Target Snapshot

CHEMBL2725 Target Snapshot

Beta-lactamase · SINGLE PROTEIN · Enterobacter cloacae

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361Compounds
159Assays
7Approved Drugs
356.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Beta-lactamase shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P05364. Start with infection, then reuse UniProt P05364 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with infection, then reuse UniProt P05364 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
infection

Beta-lactamase shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with infection because it currently carries approved-linked support. Linked drugs include RELEBACTAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-lactamase as ChEMBL target CHEMBL2725, mapped to UniProt P05364. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-lactamase
SINGLE PROTEIN · Enterobacter cloacae
As of 2026-09-13
ChEMBL target ID
CHEMBL2725
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P05364
Beta-lactamase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-lactamase is the right protein anchor across sources, using UniProt P05364 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why infection is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeta-lactamase
Target TypeSINGLE PROTEIN
OrganismEnterobacter cloacae
UniProtP05364
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-lactamase
UniProt AccessionP05364
Component TypeProtein
Sequence Length381 aa

Beta-lactamase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-lactamase, mapped to UniProt P05364. Sequence length is 381 aa.

Mapped IDP05364
Review nameBeta-lactamase
OrganismEnterobacter cloacae
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Beta-lactamase shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
infection
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Approved-linked Approved
pyelonephritis
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Approved-linked Approved
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Late clinical Phase III
bacterial disease
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Late clinical Phase III
bacterial pneumonia
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Clinical signal Phase II
hematopoietic and lymphoid cell neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with infection because it currently carries approved-linked support. Linked drugs include RELEBACTAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinfection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC50315.0
KI39.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL212760 9.0 IC50 1.0 Preclinical
CHEMBL222758 9.0 IC50 1.0 Preclinical
CHEMBL222375 9.0 IC50 1.0 Preclinical
CHEMBL122450 8.7 IC50 2.0 Preclinical
CHEMBL425963 8.7 IC50 2.0 Preclinical
CHEMBL378119 8.7 IC50 2.0 Preclinical
CHEMBL222866 8.7 IC50 2.0 Preclinical
CHEMBL222922 8.7 IC50 2.0 Preclinical
CHEMBL375172 8.7 IC50 2.0 Preclinical
CHEMBL45136 8.54 IC50 2.9 Preclinical
Distribution

pChEMBL Value Distribution

42
5.0
29
5.5
36
6.0
25
6.5
17
7.0
20
7.5
9
8.0
11
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AVIBACTAM
CHEMBL1689063
Approved 2015
Properties Compare Identifier
TAZOBACTAM
CHEMBL404
Approved 1993
Properties Compare Identifier
TAZOBACTAM SODIUM
CHEMBL1439
Approved 1993
Properties Compare Identifier
SULBACTAM
CHEMBL403
Approved 1986
Properties Compare Identifier
Assay Landscape

Assay Landscape

159
Total Assays
149
Tested Compounds
2
Assay Types
Binding — 140 assays, 149 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 139 149 6.3
cell-based format 1 0 —
Functional — 19 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 19 18 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine