Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL2731 Target Snapshot

Galanin receptor type 3 · SINGLE PROTEIN · Homo sapiens

272Compounds
7Assays
2Approved Drugs
270.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O60755. Use UniProt O60755 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O60755 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Galanin receptor type 3 as ChEMBL target CHEMBL2731, mapped to UniProt O60755. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Galanin receptor type 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2731
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O60755
Galanin receptor type 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Galanin receptor type 3 is the right protein anchor across sources, using UniProt O60755 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGalanin receptor type 3
UniProt AccessionO60755
Component TypeProtein
Sequence Length368 aa

Galanin receptor type 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Galanin receptor type 3, mapped to UniProt O60755. Sequence length is 368 aa.

Mapped IDO60755
Review nameGalanin receptor type 3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50236.0
KI27.0
KD7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL209497 8.3 Ki 5.0 Preclinical
CHEMBL225963 8.18 IC50 6.57 Preclinical
CHEMBL209498 8.1 Ki 8.0 Preclinical
CHEMBL378991 7.82 Ki 15.0 Preclinical
CHEMBL503473 7.82 Kd 15.0 Preclinical
CHEMBL267630 7.81 IC50 15.41 Preclinical
CHEMBL1873644 7.77 IC50 17.14 Preclinical
CHEMBL210288 7.77 Ki 17.0 Preclinical
CHEMBL378825 7.68 Ki 21.0 Preclinical
CHEMBL211398 7.58 Ki 26.0 Preclinical
Distribution

pChEMBL Value Distribution

29
5.0
80
5.5
43
6.0
18
6.5
14
7.0
10
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RITODRINE
CHEMBL83063
Approved 1982
Assay Landscape

Assay Landscape

7
Total Assays
171
Tested Compounds
2
Assay Types
Binding — 6 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 6 29 7.2
Functional — 1 assays, 171 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 171 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine