DNA polymerase subunit gamma-1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P54098. Use UniProt P54098 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54098 as the stable identity anchor, then attach disease evidence before program review.
DNA polymerase subunit gamma-1
Review this target as DNA polymerase subunit gamma-1, mapped to UniProt P54098. Sequence length is 1239 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA polymerase subunit gamma-1 as ChEMBL target CHEMBL2732, mapped to UniProt P54098. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA polymerase subunit gamma-1 is the right protein anchor across sources, using UniProt P54098 as the stable mapping.
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| Preferred Name | DNA polymerase subunit gamma-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P54098 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA polymerase subunit gamma-1 |
| UniProt Accession | P54098 |
| Component Type | Protein |
| Sequence Length | 1239 aa |
DNA polymerase subunit gamma-1
Review this target as DNA polymerase subunit gamma-1, mapped to UniProt P54098. Sequence length is 1239 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL483492 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL477486 | 6.1 | Kd | 800.0 | Preclinical |
| CHEMBL922 | 6.01 | Ki | 970.0 | Approved |
| CHEMBL560403 | 5.96 | Kd | 1100.0 | Preclinical |
| CHEMBL2092833 | 5.82 | IC50 | 1500.0 | Preclinical |
| CHEMBL2092835 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL3126408 | 5.52 | IC50 | 3000.0 | Preclinical |
| CHEMBL2092834 | 5.46 | IC50 | 3500.0 | Preclinical |
| CHEMBL1673 | 5.22 | Kd | 6000.0 | Preclinical |
| CHEMBL1230 | 4.89 | Kd | 13000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 26 | 15 | 5.1 |
| assay format | 3 | 2 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |