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Target Snapshot

CHEMBL274 Target Snapshot

C-C chemokine receptor type 5 · SINGLE PROTEIN · Homo sapiens

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3,477Compounds
400Assays
9Approved Drugs
5,164.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

C-C chemokine receptor type 5 shows approved-linked disease relevance led by HIV infection. 5 more disease programs remain visible in the same review block. 8 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P51681. Start with HIV infection, then reuse UniProt P51681 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with HIV infection, then reuse UniProt P51681 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 8 linked drugs
Open source guide
Disease program
HIV infection

C-C chemokine receptor type 5 shows approved-linked disease relevance led by HIV infection. 5 more disease programs remain visible in the same review block. 8 linked drugs remain visible in the same block.

Start review with HIV infection because it currently carries approved-linked support. Linked drugs include APLAVIROC HYDROCHLORIDE, CCR5MAB004, CENICRIVIROC, INCB-9471. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 8 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-C chemokine receptor type 5 as ChEMBL target CHEMBL274, mapped to UniProt P51681. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-C chemokine receptor type 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL274
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P51681
C-C chemokine receptor type 5
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-C chemokine receptor type 5 is the right protein anchor across sources, using UniProt P51681 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why HIV infection is currently framed as approved-linked support. It currently carries 8 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameC-C chemokine receptor type 5
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP51681
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-C chemokine receptor type 5
UniProt AccessionP51681
Component TypeProtein
Sequence Length352 aa

C-C chemokine receptor type 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C-C chemokine receptor type 5, mapped to UniProt P51681. Sequence length is 352 aa.

Mapped IDP51681
Review nameC-C chemokine receptor type 5
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

C-C chemokine receptor type 5 shows approved-linked disease relevance led by HIV infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
HIV infection
8 linked drugs · 8 direct · 8 efficacy
Linked drugAPLAVIROC HYDROCHLORIDE
Linked drugCCR5MAB004
Linked drugCENICRIVIROC
Linked drugINCB-9471
Approved-linked Approved
HIV-1 infection
3 linked drugs · 3 direct · 3 efficacy
Linked drugCENICRIVIROC
Linked drugLERONLIMAB
Linked drugMARAVIROC
Approved-linked Approved
viral disease
1 linked drug · 1 direct · 1 efficacy
Linked drugMARAVIROC
Late clinical Phase III
COVID-19
3 linked drugs · 3 direct · 3 efficacy
Linked drugCENICRIVIROC
Linked drugLERONLIMAB
Linked drugMARAVIROC
Late clinical Phase III
infection
2 linked drugs · 2 direct · 2 efficacy
Linked drugCENICRIVIROC
Linked drugMARAVIROC
Late clinical Phase III
non-alcoholic steatohepatitis
2 linked drugs · 2 direct · 2 efficacy
Linked drugCENICRIVIROC
Linked drugLERONLIMAB
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with HIV infection because it currently carries approved-linked support. Linked drugs include APLAVIROC HYDROCHLORIDE, CCR5MAB004, CENICRIVIROC, INCB-9471. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseHIV infection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

9
Approved
5
Phase III
7
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC503,997.0
KI1,050.0
EC50101.0
KD16.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL311795 11.0 IC50 0.01 Preclinical
CHEMBL460845 10.3 IC50 0.05 Preclinical
CHEMBL181276 10.22 IC50 0.06 Preclinical
CHEMBL21106 10.22 IC50 0.05998 Preclinical
CHEMBL457043 10.15 IC50 0.07 Preclinical
CHEMBL2164207 10.1 IC50 0.08 Preclinical
CHEMBL1926899 10.05 IC50 0.09 Preclinical
CHEMBL93139 10.0 IC50 0.1 Preclinical
CHEMBL20896 10.0 IC50 0.1 Preclinical
CHEMBL20345 10.0 IC50 0.1 Preclinical
Distribution

pChEMBL Value Distribution

143
5.0
147
5.5
248
6.0
251
6.5
437
7.0
503
7.5
472
8.0
426
8.5
270
9.0
83
9.5
pChEMBL
Approved Drugs

Approved Drugs

MARAVIROC
CHEMBL256907
Approved 2007
Properties Compare Identifier
TERFENADINE
CHEMBL17157
Approved 1985
Properties Compare Identifier
Assay Landscape

Assay Landscape

402
Total Assays
1,998
Tested Compounds
2
Assay Types
Binding — 238 assays, 1,998 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 117 1,334 7.7
single protein format 113 621 7.4
assay format 5 26 8.3
cell membrane format 3 17 6.3
Functional — 164 assays, 699 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 124 612 7.1
assay format 34 83 7.7
single protein format 3 0 —
tissue-based format 2 2 7.8
cell membrane format 1 2 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine