ATP-citrate synthase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P16638. Use UniProt P16638 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P16638 as the stable identity anchor, then attach disease evidence before program review.
ATP-citrate synthase
Review this target as ATP-citrate synthase, mapped to UniProt P16638. Sequence length is 1100 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ATP-citrate synthase as ChEMBL target CHEMBL2745, mapped to UniProt P16638. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether ATP-citrate synthase is the right protein anchor across sources, using UniProt P16638 as the stable mapping.
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| Preferred Name | ATP-citrate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P16638 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ATP-citrate synthase |
| UniProt Accession | P16638 |
| Component Type | Protein |
| Sequence Length | 1100 aa |
ATP-citrate synthase
Review this target as ATP-citrate synthase, mapped to UniProt P16638. Sequence length is 1100 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL118715 | 6.82 | Ki | 150.0 | Preclinical |
| CHEMBL2165254 | 6.55 | IC50 | 283.0 | Preclinical |
| CHEMBL119628 | 6.16 | Ki | 700.0 | Preclinical |
| CHEMBL2165261 | 6.16 | Ki | 700.0 | Preclinical |
| CHEMBL5438623 | 6.0 | Ki | 1000.0 | Preclinical |
| CHEMBL121948 | 5.92 | Ki | 1200.0 | Preclinical |
| CHEMBL420700 | 5.92 | Ki | 1200.0 | Preclinical |
| CHEMBL118918 | 5.58 | Ki | 2600.0 | Preclinical |
| CHEMBL116883 | 5.54 | Ki | 2900.0 | Preclinical |
| CHEMBL120425 | 5.54 | Ki | 2900.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 19 | 68 | 5.0 |
| assay format | 15 | 26 | 5.4 |
| tissue-based format | 5 | 7 | 5.8 |